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licensing factor
A licensing factor is a protein or complex of proteins that allows an origin of replication to begin DNA replication at that site. They are thought to primarily occur in eukaryotic cells, since prokaryotes use simpler systems to initiate replication.
==Function of licensing factors==
Origins of replication represent start sites for DNA replication and so their "firing" must be regulated to maintain the correct karyotype of the cell in question. The origins are required to fire only once per cell cycle, an observation that led to the postulated existence of licensing factors by biologists in the first place. If the origins were not carefully regulated then DNA replication could be restarted at that origin giving rise to multiple copies of a section of DNA. This could be damaging to cells and could have detrimental effects on the organism as a whole.
The control that licensing factors exert over the cycle represents a flexible system, necessary so that different cell types in an organism can control the timing of DNA replication to their own cell cycles. false
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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